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Phase III clinical trials have reported febuxostat to be more effective than allopurinol at a dose of 300mg

cFOS whole-brain imaging Lean male C57BL/6J mice (aged 8 weeks) maintained on a chow diet (Brogaarden, Altrumin, 1310) were randomized 4 days before the study start and treated with once-daily s.c

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Notably, during ischemiareperfusion (IR), when blood oxygenation to ischemic tissue is restored, neurons exhibit a preference for glycolysis as their primary energy source, even in the presence of adequate oxygen supply (19, 20)