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Despite its advantages, its important to acknowledge GHK-Cus limitations when compared to traditional acne treatments in a research context: Limited Direct Evidence for Active Acne Vulgaris: While it has anti-inflammatory properties, there is currently limited direct clinical evidence specifically demonstrating GHK-Cu as a primary treatment for active acne breakouts (e.g., reducing papules, pustules, or cysts)

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Autocrine/paracrine roles of extrapituitary growth hormone and prolactin in health and disease: an overview

Room-temperature storage shortens the safe-use window from 28 days to roughly 24 hours