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Practice guideline: treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology

Several possible explanations: The patent holder may not have found a pharmaceutical company willing to invest in the expensive process of clinical development

Lightening products are recommended preferably for nighttime use because using lightening/brightening skincare during the day makes the skin more sensitive to sunlight, resulting in darker skin, uneven skin tone and wrinkling over time

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