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KIF12-associated impaired functional cell polarity may be the underlying cause

Part A was a double-blind, placebo-controlled, sequential, single-ascending-dose safety study of ImmTOR, and Part B was an open-label, sequential, single-ascending dose study of SEL-212, a combination product candidate consisting of a fixed dose of pegadricase combined with ascending doses of ImmTOR, in patients with hyperuricemia with or without a clinical diagnosis of gout (Fig

Proc Natl Acad Sci USA.9157405747

Integrated multi-omics identified the novel intratumor microbiome-derived subtypes and signature to predict the outcome, tumor microenvironment heterogeneity, and immunotherapy response for pancreatic cancer patients

Annu Rev Genet 45:167202 Alt FW, Zhang Y, Meng FL, Guo C, Schwer B (2013) Mechanisms of programmed DNA lesions and genomic instability in the immune system