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However, their clinical translation has been hindered by poor water solubility, rapid metabolism, low bioavailability, and fast excretion

Epidemiology of neuropathic pain: An analysis of prevalence

Neutralizing antibody against PAI-1 attenuated p65 activation in IL-1 treated hepatocytes and blocked PAI-1 induction completely, suggesting the freely released PAI-1 is required to fully activate p65 and induce PAI-1