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Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and -Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer's Disease

pretreated with aqueous-methanolic(Compositae) (500 mg/kg) also had the hepatoprotective effects by reducing ALT and AST levels, and inhibiting microsomal drug-metabolizing enzymes (Gilani and Janbaz, 1995a)