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1 The diagnosis of Lyme disease consists of a two-tiered serologic testing, which includes an enzyme-linked immunosorbent assay (ELISA) followed by a Western blot, 9 and is only recommended by the CDC for symptomatic patients

FIGURE 1 Measure of skin lesion, dermatitis score, and ear thickness The ear thickness was measured the day after each DNCB application by using an electronic vernier caliper (Decimal Caliper, Asa Dental spa, Lucca, Italy) and a digital camera to record clinical symptoms

Interestingly, there is broad overlap between substrates for and inhibitors of CYP3A enzymes and p-glycoprotein ( CYP3A4 is the most abundant CYP3A isoform in the intestine and liver (Nebert and Russell, 2002)

The variability in probiotic strains and synbiotic combinations also affects the reproducibility and standardization of antidiabetic outcomes (Nurliyani et al., 2022

Cu, Zn-SOD (SOD1) is a homodimer and contains copper and zinc ions