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For example, MnTE-2-PyP, a superoxide dismutase mimic, can reduce pulmonary vascular inflammation by scavenging oxygen free radicals in lung tissue, thereby inhibiting the levels of the NLRP3 inflammasome, caspase-1, IL-1, and IL-18 from alleviating pulmonary vascular remodeling [130]

These external sources of oxidative stress highlight the importance of the bodys internal antioxidant defense systems [32], which encompass both enzymatic and non-enzymatic mechanisms by maintaining redox balance and preventing cellular damage

MI is defined pathologically as the death of cardiomyocytes resulting from chronic myocardial ischemia, characterized by a reduced oxygen supply to the myocardium [57]

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Mice were treated with erastin as described above