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It is possible that co-localisation of WLP proteins in the cytoplasm may cause the reduction of H 13 CO 3 at a higher ratio than expected (i.e

Hypotheses include an effect of metformin on the intestinal flora leading to bacterial overgrowth and B12 malabsorption, and an indirect effect of metformin on the enterohepatic circulation of B12

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All cells require NADPH for reductive detoxification, and most cells require ribose-5-phosphate for nucleotide synthesis