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100 Overexpression of the multifunctional adiponectin omentin-1 inhibits ER stress in the colon tissue of UC mice and attenuates colon injury and inflammatory cell infiltration

When the finely-tuned trafficking of macromolecules is dysregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune disorders can occur.[105] There is growing evidence that increased intestinal permeability plays a pathogenic role in various autoimmune diseases

Unlike the other GUSs, the TIM barrel domains of the two neighboring subunits in Bf GUS do not face each other (Fig