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Dec 2022;15(12):1477-1483

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Thus, NACs neuroprotective effects may involve its ability to reduce cortical spermidine levels and thereby limit local excitotoxic effects in the PFC during THC exposure, further indicated by our electrophysiological findings demonstrating a hyperactive neuronal mPFC phenotype

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It has been proposed that most GCs are synthesized via transamidination of the amidino group from arginine to amino acids and neurotransmitters [1] (Figure 1)

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