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During brain maturation, repeated or prolonged stress can induce enduring changes in neural circuits and molecular pathways, leading to impairment in emotional and cognitive processing [3-5]

Issa GC , Ambinder AJ, Xiao W, Manalis S, Shalek AK, Gondek LP, Kentsis A, Short NJ, Daver N, Ning J, Xiao L, Hemann M, Chen K, Patel KP, Bachireddy P, Lane AA, Konopleva M, Abdel-Wahab O, Molldrem JJ, Levine RL, Levis MJ, Stone RM, Andreeff M , Ravandi F, Goldberg AD, Garcia JS

Essential Safety Measures Pre-infusion assessment: Every patient should undergo a medical history review, current medication assessment, and relevant laboratory testing before receiving IV therapy