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Suppression of cancer activators such as NFB serves to down regulate inflammatory cytokines, responsible for tumorigenesis [55]

If ETC function is impaired, the TCA cycle can continue to generate metabolites by reductive mechanisms, including using pyruvate carboxylase to generate oxaloacetate from pyruvate for aspartate production, and glutamine-dependent reductive carboxylation for citrate synthesis (22, 23)

In addition, western blot results showed that the expression level of GPX4 in the spinal cord of painful rats was significantly downregulated

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K., Barbeiro, D