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Alleviating inflammation Oxygen glucose deprivation/reoxygenation (OGD/R) or I/R induced the upregulation of inducible nitric oxide synthase (iNOS), cyclooxygenases 2 (COX2) and the releasing of proinflammatory cytokine interleukin 1 beta (IL-1) and tumor necrosis factor- (TNF-) (Chen et al., 2018)

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Recent studies have shown that inflammation is a key marker of the aging ovarian stroma and is considered a new mechanism of POI (Huang et al., 2019b

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Yet, it remains unclear whether ferroptosis serves primarily as a downstream effector, an upstream driver, or part of a self-amplifying feedback loop in disease progression