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Metabolomics analysis of plasma and erythrocytes also revealed a close relationship between childhood obesity, IR, and multiple lipid classes

Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB, et al

The transgenic plants showed more accumulation of MDA compared with WT under cold stress, which suggested a higher degree of lipid peroxidation in transgenic plants (Figure 7B)

Conclusion: FXR314, administered orally once daily for 16 weeks, demonstrated dose dependent target engagement, improvement in hepatic fat and biochemical markers and was safe and well tolerated with a unique safety profile compared to other FXR agonists