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Caffeine interactions with medications can potentially increase the side effects of the drugs, leading to toxicity, or reducing the effectiveness of the drug therapy For example, diuretic drugs (water pills) decrease potassium, and caffeine decreases potassium, so taking them together can lead to low blood potassium levels

Trushina, C

Yotova, I

Front Med (Lausanne) (2021) 8:702638

Phase 1b/2a Subcutaneous Formulation (Obesity) Published: The Lancet, June 2025 Participants: 125 adults with overweight or obesity (BMI 27.039.9), aged 1855 Duration: Up to 36 weeks Dosing: Once-weekly subcutaneous amycretin, up to 60 mg Results: - Up to 22% absolute weight loss at 36 weeks (highest dose group) - Placebo-adjusted difference: approximately 24% - No weight-loss plateau observed at study end Safety: 81% of the 89 participants who reported a TEAE had gastrointestinal events