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Complexes I and III of the mitochondrial electron transport chain, which transforms 13 percent of total oxygen into the superoxide anion, is the primary source of O2in a cell (102)

Results: rAAV8-mediated knockdown of Capn4 mediated a robust and stable suppression of hepatic Capns1 expression, coupled with a nearly complete abrogation of detectable Capn1/2 enzyme activity

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