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Acknowledgements SLS-P thanks International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India and the Department of Biotechnology (DBT), Government of India for funding research

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Glucagon-like peptide 1 recruits muscle microvasculature and improves insulins metabolic action in the presence of insulin resistance

Treatment doses depend on the cause: pernicious anaemia typically requires intramuscular hydroxocobalamin 1,000 micrograms three times weekly initially, whilst dietary deficiency may be treated with oral cyanocobalamin 50150 micrograms or 1,000 micrograms daily