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Figure 4 Western Blot analysis of purified anti-DNA antibodies of normal individual and SLE patients

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10.1212/wnl.44.9.1600 139 LuH.LiuX.DengY.QingH

However, KYNA influences AMPAR activity predominantly through indirect mechanisms, namely its non-competitive allosteric inhibition of presynaptic 7nAChRs on glutamatergic terminals in mood-related circuits, leading to reduced glutamate release and downstream modulation of excitatory signalling [29, 30]