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Resistance to osimertinib, a third-generation tyrosine kinase inhibitor targeting EGF receptor used as first-line therapy for patients with non-small cell lung cancer (NSCLC) harboring mutant EGFR, is mediated by IGF-1R signaling activated by IGF-2 in NSCLC cell lines (41)

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Future efforts should prioritize the identification of efficient, low-toxicity targets and the development of specific inhibitors

USD 39.95 Prices may be subject to local taxes which are calculated during checkout Similar content being viewed by others References Takano, T

Given their tissue-specific expression patterns and functional pleiotropy, FABPs are positioned at the intersection of energy balance, lipid metabolism, and inflammatory signaling, and FABP dysregulation is repeatedly linked to IR and T2DM