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Description

Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H1 receptor and TRPV1

Researchers identified N-alkyl-4-picolinium (NAP) as an efficient caging group that releases active molecules upon exposure to radiation

These additions include an accessory TMD called TMD0, a Lasso motif that connects TMD0 and TMD1, and a ~60 to 140 amino acid disordered domain termed the regulatory domain (R-domain) that connects NBD1 and TMD2 10,11,12,13