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However, the transient interaction with IgM is sufficient to deposit sublytic quantities of C3b, an excellent opsonin, which leads to the removal of red cells by phagocytes in the spleen, liver, and bone marrow (extravascular hemolysis)

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doi: 10.1136/annrheumdis-2017-212288 19 DalileB.Van OudenhoveL.VervlietB.VerbekeK

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For cultured astrocytes, the processes that are mainly responsible for the consumption of intracellular GSH aredepending on the experimental conditions appliedthe oxidation of GSH to GSSG by GPx, the conjugation of GSH with electrophiles, and/or the export of GSH, GSSG, and GSHconjugates (Figure 2)

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