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73(6): 1009 Nebel A, Schneider BJ, Baker RK, et al

The MELK inhibitor OTSSP167 protects intestinal epithelial cells by maintaining a normal composition of gut microbiota and balancing gut microbiota distribution, inhibiting ferroptosis, reducing the expression of pro-inflammatory factors in intestinal tissues, and suppressing the AKT/IKK/P65 and ERK/IKK/P65 signaling cascades in vitro and in vivo, thereby exerting a protective effect on the intestinal tissues of colitis mice [291, 292]

Treatment may involve prescribing allergy medications, antidepressants, or pain relievers, which can provide temporary relief but fail to address the underlying toxic burden