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Progression of diabetic nephropathy was defined as transition in albuminuria class (i.e., normoalbuminuria to microalbuminuria, microalbuminuria to macroalbuminuria, or normoalbuminuria to macroalbuminuria) and/or a greater than 2-fold increase of serum creatinine at follow-up compared with the baseline value

Zhuang W, Li B, Long L, Chen L, Huang Q, Liang Z

Protection by superoxide dismutase, catalase, poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis

Although mild oxidative stress can lead to modest NF-B activation, extensive oxidative stress can inhibit NF-B [123]