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When excessive iron accumulates in the mitochondria, Fe 2+ generates a large amount of hydroxyl radicals (OH) through the Fenton reaction, resulting in mitochondrial dysfunction and structural damage (Abe et al., 2022)

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doi: 10.7326/0003-4819-121-12-199412150-00009 14 CarruthersBMJainAKDe MeirleirKLPetersonDLKlimasNGLernerAMet al

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3 : 161170 Dhein J, Walczak H, Bumler C, Debatin KM and Krammer PH (1995) Autocrine T cell suicide mediated by APO-1 (Fas/CD95)

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Liu X, Hong L, Nilsson M, Hubert SM, Wu S, Rinsurongkawong W, Lewis J, Spelman A, Roth J, Swisher S , He Y, Jack Lee J, Fang B, Heymach JV, Zhang J, Le X

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