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The Mediterranean and Middle East face challenges with Leishmania infantum and Leishmania tropica , where antimonial resistance is emerging, leading to increased reliance on L-AmB

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Regulation of the IL-17/Th17 response by NLRP3, neutrophil extracellular traps, and extracellular histones leads to exacerbating bone resorption ( P.g disrupts gut linoleic acid (LA) metabolism, activates Th17, suppresses Tregs, and exacerbates colitis, and these effects could be reversed by LA supplementation ( P.g , intestinal Candida albicans ( C.a ) taken in by the mucosal immune system induces pathobiont-reactive Th17 cells, while these Th17 cells migrate from the gut to the mouth upon oral infection, thereby inducing Th17 responses in the tongue during oropharyngeal candidiasis ( In addition to the aforementioned IL-17, other pro-inflammatory cytokines, such as IL-1, IL-6, and TNF-, also play important roles in the immune interaction between the oral-gut axis and systemic diseases

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