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There are no large-scale randomized human trials establishing therapeutic ranges

Acknowledgments We thank the UK Biobank study, and the summary statistics data of UKB can be download from Neale lab ( and other GWAS summary-level data, which have been downloaded from We also thank all the reviewers and editors for their useful suggestions for improving this study

PMID: 21795440

Most patients begin noticing reduced cravings and improved appetite control within 12 weeks, with visible weight-loss results typically appearing around 46 weeks