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PMC 2544566

Total estimates of military service members suffering TBIs between 2001 and 2010 range from 180,000 to 320,000 (U.S

Follow institutional protocols or product labeling for guidance on maximum duration of use after opening (typically ranging from hours to days depending on clinical setting and protocol)

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The analgesic effects appeared to differ from typical opioid analgesia they developed more slowly, persisted longer after administration ceased, and showed different patterns of tolerance development