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Research shows that subjects using IGF-1 LR3 during a 20% caloric deficit while maintaining high protein intake lost fat without measurable lean mass reduction, whereas those with protein intake below 1.6 g/kg showed no advantage over placebo

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Still, as metformin inhibits the respiratory chain complex I, and FH deficiency leads to a decreased OXPHOS activity, it is unclear whether this treatment would be beneficial [118]