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Full text: #MALO #VCTE #FIB4 CUHK Medicine To view or add a comment, sign in (NASDAQ: #DNLI) The New England Journal of Medicine has published Phase 1/2 data showing Denalis Hunter syndrome drug tividenofusp alfa (DNL310) can cut cerebrospinalfluid heparan sulfate by about 90% to normal or nearnormal levels and improve or stabilize cognition, behavior, hearing, liver size, and other clinical measures in most treated children, bolstering its case for FDA priority review and potential accelerated approval

Cellular and molecular mechanisms of the bloodbrain barrier dysfunction in neurodegenerative diseases

Elevated expression levels of collagen IV in the BM have been identified in the post-mortem brains of PD patients

Not an approved product: GLP-1 agonists carry documented class cautions thyroid C-cell tumors seen in rodents (human relevance uncertain), pancreatitis signals, and gallbladder events [5] and the combination itself has not been reviewed or cleared by any regulator

Bottom line: They pad the list, kill engagement, and slowly erode deliverability