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doi: 10.2147/CCID.S57600

The discovery of homozygotic risk genes in most of the very rare (probably less than 1%) cases of early onset Alzheimers disease which share increased production of -amyloid (A) as one (but probably not the only one) common property led to the amyloid-cascade hypothesis, assuming A as the major if not the only causative factor for the development of AD

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