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Cyclosporine treatment for Stevens-Johnson syndrome/toxic epidermal necrolysis: retrospective analysis of a cohort treated in a specialized referral center

10.5665/sleep.4064 2 AsherG.GatfieldD.StratmannM.ReinkeH.DibnerC.KreppelF.et al

As we age, or when we are under constant stress, our natural production of glutathione begins to decline

We have solved the structures of the pi class GST hP1-1 in complex with its substrate, glutathione, a transition-state complex, the Meisenheimer complex, and an inhibitor, S-(rho-bromobenzyl)-glutathione, and refined them to resolutions of 1.8 A, 2.0 A and 1.9 A, respectively