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Conclusion In summary: with concurrent measurement of GABA+, Glx and BOLD in response to a cognitive task, we obtained behavioural, functional MR and spectroscopy findings consistent with literature based on separate acquisition of fMRI and MRS, and indicative of an executive and attentional deficit

Medications such as histamine 2 receptor antagonists and proton pump inhibitors (PPIs) (lansoprazole, omeprazole, and esomeprazole) that suppress gastric acid may lower total serum B12 levels by impairing the release of B12 from food (Damodharan et al., 2021

Table 4 Comparison of adverse reactions between control group and treatment group [n (%)]

Peer review Peer review information Nature Biomedical Engineering thanks the anonymous reviewers for their contribution to the peer review of this work