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Application Areas: Metabolic Disease Research: Obesity, insulin resistance, type 2 diabetes mechanism and drug development Aging and Longevity Research: NAD+ homeostasis, mitochondrial function, regulation of cell aging pathways Neuroscience Research: Exploration of protective effects on neurodegenerative diseases such as Parkinsons disease Sports Science: Enhancing endurance, promoting muscle repair and improving physical performance research

1a and part of Supplementary Table 1.

Pan Q, Jiang L, Xiong Y, Chao FL, Liu S, Zhang SS, et al

Most protocols recommend consistent use over several weeks to months

IFN- 8 and IFN-stimulated gene expression 11 colocalize with HLA-I hyper-expression, which is a histopathological hallmark of T1D in insulin (INS)-containing islets 12