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Changes in lipid metabolism and related signaling pathways in cancer are shown in Fig

In this study using obese rats, researchers investigated how tesofensine suppresses appetite

87 The lack of robust human data is the elephant in the room: we simply dont have the clinical trials to know if the amazing results in rats will translate to people, or if long-term use might introduce serious side effects

provided evidence that the interplay between the signals of mechanistic target of rapamycin kinase (mTOR) and GPX4 modulates autophagydependent ferroptosis in human pancreatic cancer cells, and the downregulated expression of GPX4 enhances the anti-cancer activity of rapamycin in vitro or in vivo by promoting ferroptosis and suppressing autophagy [38]