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Furthermore, TGP activates the PI3K/Akt signaling pathway to enhance melanocyte survival, while also inhibiting the NF-B pathway to reduce pro-inflammatory cytokine release and inflammation-induced melanocyte damage ( 10 Problems with current research and directions for future research 10.1 Problems with current research Research on TGP in the treatment of dermatologic diseases has demonstrated significant anti-inflammatory, immunomodulatory, and antioxidant effects, but there are several limitations

Shown here are the dose-dependent effects of supplementation on 25-hydroxyvitamin D levels from round 1 to round 2, with individuals taking less than 3000 IUs/day exhibiting relatively little gains in 25-hydroxyvitamin D levels