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Thus, specific targeting of IGF-1R signaling post development may prove to be the best approach to achieve the benefits of low growth signals on healthspan and aging, without the potential unwanted side effects of combined adult-onset GH/IGF-1 deficiency

In this study we tested whether some of these compounds can bind proteins involved in neurodevelopmental processes, using a computational approach

In silico analysis identified Glo1 as the only druggable target upregulated after trabectedin treatment and correlated with poor prognosis

Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin