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Start with lower concentrations and gradually increase as skin tolerance develops

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The ketogenic diet increases ketone bodies such as beta-hydroxybutyrate, which provides an alternate energy source to neurons, thus offering neuroprotection and reduced neuroinflammation (146)

While patients do often see a flare-up in acne breakouts when they first begin taking Accutane, these breakouts should clear up within the first few weeks of treatment, and patients will continue to see improvement throughout the time theyre taking isotretinoin