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Transient increase in heart rate with rapid administration

Collectively, these mechanisms promote a sustained negative energy balance and clinically meaningful weight loss

Interestingly, we found that only VitB12 levels were significantly increased in the insomniac group and independently associated with the presence of insomnia after adjusting for confounding factors (which differed between the two groups and have been shown to impair sleep)

The necessity for appropriate comparators and the patient-specific nuances of TE interventions pose challenges in conducting traditional randomized controlled trials (RCTs) or extrapolating findings across patients