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Beyond intestinal dysbiosis, recent research has shown that microbial metabolites influence immunological tone by acting on receptors such as GPR41/43, AhR, and FXR, regulating cytokine secretion, T-cell differentiation, and microglial activity [100]

This finding might indicate that the detoxification process in this bacterium is mainly dependent on the GST pathway, which can catalyse the reaction of GSH with the substrates of toxic compounds (e.g., the residual chlorine in DW) and thus prevent these compounds from interacting with crucial cellular proteins or nucleic acids 23

DiSCaGe 29 calculated a gene mutation score using an asymmetric spreading strength based on the type of mutations and the PPI network, then produced a ranking of prioritized cancer risk genes

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Endocrinol Diabetes Metab Case Rep