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Aging is associated with progressive decline in GH and IGF-1 levels - by age 60, many individuals have GH secretion that is 50-70% lower than peak young adult levels, a phenomenon sometimes called somatopause

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Age of the sermorelin evidence

[7] That preclinical promise carried the compound into a human Phase II program for postoperative ileus but the randomized, placebo-controlled trial in bowel-resection patients did not meet its primary efficacy endpoint, and clinical development was subsequently discontinued