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This DNA-trabectedin adduct interacts with DNA repair proteins of the transcription-coupled nucleotide excision repair DNA-repair system which causes cell death via the formation of double-strand breaks mainly in homologous recombination-deficient cells [129]

Pyrocatechol has also been reported to mimic anti-oxidant effects through the activation of Nrf2, heme-oxygenase-1 (HO-1), and NQO-1 (22)

However, randomized controlled trials are needed to determine whether antioxidant supplements slow or prevent age-related cognitive decline

Glutathione also provides anti-aging benefits by reducing oxidative stress and promoting a youthful, radiant complexion

For each of these proteins, alignments of the homologs were created from Uniprot clusters and Blast searches