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The foundational studies by Monnier, Schoenenberger, and colleagues who first isolated DSIP from rabbit brain venous blood during electrically-induced sleep demonstrated that intravenous or intraventricular administration of DSIP to rabbits and rats could induce behavioral and EEG changes consistent with sleep, particularly increases in slow-wave sleep

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But these can be secondary to problems with B12, and in that case, giving folic acid or methylfolate would be a mistake

Clinical trials have shown that semaglutide can reduce body weight by 15% or more over 68 weeks