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Results JA, OPDA and GSH are involved in regulation of gene expression during recovery from HL treatment Global gene expression analysis was performed after the HL treatments of 15 and 60 min (HL15 and HL60) and after subsequent R phases in GL for 15 (R15) and 60 min (R60), and the results were expressed with respect to GL control without any HL treatment

This sharp increase in intracellular Ca2+ concentration is the principal trigger for the fusion of GH-containing secretory vesicles with the somatotroph cell membrane, resulting in the exocytosis and release of GH into circulation

In light of the safety concerns surrounding the utilization of bEVs for drug delivery or as vaccines, there exist several strategies that can be employed to improve immunogenicity and mitigate potential toxic effects

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