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As we grow older, the production of copper peptides naturally declines, which is why some skincare companies and incorporating them into topical formulations

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In most clinical situations the drug concentration is much less than the Michaelis constant, so the equation reduces to the following: that is, the rate of drug metabolism is directly proportional to the concentration of free drug and first order kinetics are observed in that a constant fraction of drug is metabolized per unit of time

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