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The remaining needle height was measured and recorded as a percentage of the original height over time [28]

Perluigi et al., 2012

Early NRTIs such as Zidovudine (AZT), Stavudine (d4T) and Didanosine (ddI) had a higher affinity for Pol- and consequently produced substantial mitochondrial toxicities, including lactic acidosis, hepatic steatosis, peripheral neuropathy, and lipoatrophy (104, 105)