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Despite their effectiveness, these treatments are accompanied by potential side effects and risks

In this context, phytochemicals, with their wide availability, structural diversity, favorable safety profiles, and capacity to regulate multiple biological targets, have emerged as valuable resources for novel drug development ( Here we summarize the critical role of microglia-mediated neuroinflammation in morphine tolerance, with a particular focus on summarizing recent research on phytochemicals that modulate microglial function to alleviate morphine tolerance

Lesley, J., Kincade, P