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doi: 10.3389/fimmu.2023.1175874 Received 28 February 2023 Accepted 03 April 2023 Published 14 April 2023 Volume 14 - 2023 Edited by Burcu Zeydan, Mayo Clinic, United States Reviewed by Dimitry N

Due to the complexity, and size limitations associated with the cobalamins, the primary method for calculating ground state properties is density functional theory (DFT), while time-dependent DFT (TD-DFT) is used for electronically excited states