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It also plays the role of coenzyme of oxidation enzymes such as proline hydroxylase, lysine hydroxylase, 4-hydroxyphenylpyruvate dioxygenase, dopamine--hydroxylase, tryptophan hydroxylase, and -butyrobetaine hydroxylase [9]

Figure1 GHK-Cu was tested for effects of hair growth in 30-day old Swiss-Webster mice

Comparing with wild genotype (CC), the heterozygote (CT) and mutation homozygote (TT) lead to the decline of enzyme activity by about 34 and 75%, and increased thermolability in lymphocyte extracts 25

Moreover, by analyzing differing CuRG expression profiles, the study classified ALS patients into two distinct pathological subtypes with marked differences in immune characteristics and biological processes, highlighting the complex interplay between abnormal copper metabolism and immune responses in ALS pathogenesis (111)

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