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It was found that CD8 + T cells were responsible for driving a significant reduction in tumor volume upon treatment with NF611 upon CD8 blockade in vitro and in Rag1 -/- mice in vivo

Another study demonstrated that depletion of deubiquitinase UPS30 in fly may rescue Parkin/PINK1-dependent mitophagy and counteract PD-like symptoms of paraquat-induced decreased dopamine level and motor dysfunction 46

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Tau deficiency may also disrupt iron release via APP expression regulation, leading to intracellular iron accumulation, iron deposition, and pathological Tau changes, further aggravating ferroptosis and neuronal damage (Duce et al., 2010

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